From Chapter 1:
"Tarlton, as other gentlemen used, at the first comming up of tobacco, did take it more for fashion's sake than otherwise, and being in a roome, set between two men overcome with wine, and they never seeing the like, wondered at it, and seeing the vapour come out of Tarlton's nose, cryed out, fire, fire, and threw a cup of wine in Tarlton's face. Make no more stirre, quoth Tarlton, the fire is quenched: if the sheriffes come, it will turne to a fine, as the custome is. And drinking that againe, fie, sayes the other, what a stinke it makes; I am almost poysoned. If it offend, saies Tarlton, let every one take a little of the smell, and so the savour will quickly goe: but tobacco whiffes made them leave him to pay all."

From Chapter 8:
Parr is said on one occasion to have called for a pipe after taking a meal at a coaching-inn called the "Bush" at Bristol, when the waiter told him that smoking was not allowed at the Bush. Parr persisted, but the authorities at the inn were firm in their refusal to allow anything so vulgar as smoking on their premises, whereupon Parr is said to have exclaimed: "Why, man, I've smoked in the dining-room of every nobleman in England. The Duchess of Devonshire said I could smoke in every room in her house but her dressing-room, and here, in this dirty public-house of Bristol you forbid smoking! Amazing! Bring me my bill." The learned doctor exaggerated no doubt as regards the facilities given him for smoking; for it was his overbearing way not to ask for leave to smoke, but to smoke wherever he went, whether invited to do so or not; but the story shows the prejudice against smoking which was found in many places as a result of the attitude of the fashionable world towards tobacco.