From Chapter 1:
"'It requires no effort of the fancy to picture these three men [Shakespeare, Bacon and Raleigh] as lounging in a window of Durham House, puffing the new Indian weed from silver bowls, discussing the highest themes in poetry and science, while gazing on the flower-beds and the river, the darting barges of dame and cavalier, and the distant pavilions of Paris garden and the Globe.'" This is a pure "effort of the fancy" so far as Bacon and Shakespeare are concerned. Shakespeare's absolute silence about tobacco forbids us to assume that he smoked; but of Raleigh the picture may be true enough. The house had, as Aubrey tells us, "a little turret that looked into and over the Thames, and had the prospect which is as pleasant perhaps as any in the world"; and it would be strange indeed if the owner of the noble house did not often smoke a contemplative pipe in the window of that pleasant turret.

From Chapter 5:
When excavations were in progress early in 1901, preparatory to the construction of Kingsway and Aldwych, they included the removal of bodies from the burying-grounds of St. Clement Danes and St. Mary-le-Strand; and among the bones were found a couple of the curious tobacco-pipes called "plague-pipes," because they are supposed to have been used as a protection against infection by those whose office it was to bury the dead. These pipes have been dug up from time to time in numbers so large that one antiquary, Mr. H. Syer Cuming, has ventured to infer that "almost every person who ventured from home invoked the protection of tobacco."