From Chapter 4:
Among the documents in the possession of the Society of Antiquaries of Scotland there is a letter patent under the great seal of Charles I, in 1634, granted for the purpose of correcting the irregular sales and restraining the immoderate use of tobacco in Scotland. The letter states that tobacco was used on its first introduction as a medicine, but had since been so largely indulged in and was frequently of such bad quality, as not only to injure the health, but deprave the morals of the King's subjects. These were sentiments worthy of King James. Mr. Matthew Livingstone, who has calendared this document, says that the King therein proceeds, in order to prevent such injurious results of the use of tobacco, to appoint Sir James Leslie and Thomas Dalmahoy to enjoy for seven years the sole power of appointing licensed vendors of the commodity. These vendors, after due examination as to their fitness, were to be permitted, on payment of certain compositions and an annual rent in augmentation of the King's revenue, to sell tobacco in small quantities. The letter further directs that the licensees so appointed shall become bound to sell only sound tobacco—an admirable provision, if a trifle difficult to enforce—and to keep good order in their houses and shops. "The latter clause," adds Mr. Livingstone, "would almost suggest that the tobacco was to be sold for consumption on the premises,"—as I have no doubt it was—"and that the smokers were probably in the habit at their symposiums of using, even as they may still, I dare say, other indulgences not so soothing in their effects as the coveted weed"—a suggestion for which there seems little foundation in the clause to which Mr. Livingstone refers.

From Chapter 5:
At the time of the Great Plague all kinds of nostrums were sold and recommended as preservatives or as cures. Most of these perished with the occasion that called them forth; but the names of some have been preserved in a rare quarto tract which was published in the Plague year, 1665, entitled "A Brief Treatise of the Nature, Causes, Signes, Preservation from and Cure of the Pestilence," "collected by W. Kemp, Mr. of Arts." In the list of devices for purifying infected air it is stated that "The American Silver-weed, or Tobacco, is very excellent for this purpose, and an excellent defence against bad air, being smoked in a pipe, either by itself, or with Nutmegs shred, and Rew Seeds mixed with it, especially if it be nosed"—which, I suppose, means if the smoke be exhaled through the nose—"for it cleanseth the air, and choaketh, suppresseth and disperseth any venomous vapour." Mr. Kemp warms to his subject and proceeds with a whole-hearted panegyric that must be quoted in full: "It hath singular and contrary effects, it is good to warm one being cold, and will cool one being hot. All ages, all Sexes, all Constitutions, Young and Old, Men and Women, the Sanguine, the Cholerick, the Melancholy, the phlegmatick, take it without any manifest inconvenience, it quencheth thirst, and yet will make one more able, and fit to drink; it abates hunger, and yet will get one a good stomach; it is agreeable with mirth or sadness, with feasting and with fasting; it will make one rest that wants sleep, and will keep one waking that is drowsie; it hath an offensive smell to some, and is more desirable than any perfume to others; that it is a most excellent preservative, both experience and reason do teach; it corrects the air by Fumigation, and it avoids corrupt humours by Salivation; for when one takes it either by Chewing it in the leaf, or Smoaking it in the pipe, the humors are drawn and brought from all parts of the body, to the stomach, and from thence rising up to the mouth of the Tobacconist, as to the helme of a Sublimatory, are voided and spitten out."