From Chapter 1:
Perhaps the most likely scene of Raleigh's first experiments in the art of smoking was Durham House, which stood where the Adelphi Terrace and the streets between it and the Strand now stand. This was in the occupation of Sir Walter for twenty years (1583-1603), and he was probably resident there when Hariot returned from Virginia to make his report and instruct his employer in the management of a pipe. Walter Thornbury, in his "Haunted London," referring to the story of the servant throwing the ale over his smoking master, says: "There is a doubtful old legend about Raleigh's first pipe, the scene of which may be not unfairly laid at Durham House, where Raleigh lived." The ale story is mythical, but it is highly probable that Sir Walter's first pipes were smoked in Durham House. Dr. Brushfield quotes Hepworth Dixon, in "Her Majesty's Tower," as drawing "an imaginary and yet probable picture of him and his companions at a window of this very house, overlooking the 'silent highway':

From Chapter 6:
But so early as 1655 there is a sign of change of custom—a change, that is, in the direction of restricting and limiting the hitherto unbounded freedom granted to the use of tobacco. The London Society of Apothecaries on August 15, 1655, held a meeting for the election of a Master and an Upper Warden; and from the minutes of this meeting we learn that by general consent it was forbidden henceforward to smoke in the Court Room while dining or sitting, under penalty of half a crown.